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Only tool specifically designed to
automate the process of creating and optimizing small
interfering RNA sequences (siRNA).
Works exactly the way a molecular
biologist would structure the task.
Saves time and money and allows the
molecular biologist to explore a large number of sequence
possibilities.
RNA interference, described by Science as the
breakthrough of the year, is one of the most powerful molecular
biology tools, with a wide variety of applications. RNA
interference is silencing of a gene caused by the introduction of
a homologous dsRNA. The success of a RNA interference experiment
is heavily dependent on the design of short interfering RNA, for
efficiency and specificity. iRNAchek™ provides a
comprehensive and intuitively designed environment for the
organization of sequence data, design of siRNAs, and tracking and
analysis of successful templates. Features include:
Search based on specific region - iRNAchek™
designs the siRNA based on the regions of interest. These
regions can be set based on Open Reading Frames, introns,
exons, UTR regions and other sequence annotations. There is
also an ability to eliminate templates from specific regions.
Motif Search - It is essential to design
siRNA targets that do not fall within functionally significant
motifs and domains of the sequence. iRNAchek™ takes care of
this efficiently through the use of a filter to refine the
results based on Motif and Domain searches.
Hairpin Loop search - The efficiency of
siRNA is sometimes affected by the existence of stable hairpin
loops. This tool identifies all possible hairpin loop
formations and sorts them on the basis of their stabilization
energy. The user has an option to filter siRNA's overlapping
with selected hairpin loops.
Statistical Analysis - iRNAchek™ has a
unique tool that keeps track of successful templates and uses
statistical techniques to convert the information contained in
siRNA fragments into knowledge. This tool helps the user to
design targets with better efficacy.
BLAST Tool - iRNAchek™ helps the user
select specific siRNA's using an intuitively designed BLAST
tool. Through this tool the user can search for potential
matches from the NCBI database or create their own proprietary
database and search for matches against these databases for
possible matches.
Additional
Resources:
Click
here to start the download and trial process.
